SDHA Rabbit Monoclonal Antibody(ARA900)

Key features and details

Reactivity: Human, Mouse, Rat, Zebrafish
Application: IHC
Host: Rabbit
Clonality: Monoclonal
Target: SDHA

Brand:

CAT.NO. : ARA6735

US$ Please choose

Size:

100μL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.

Application

Application	Dilution Ratio
IHC-P	1:1000-1:5000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Synthetic peptide within Human SDHA aa 581-624 / 664
Species Reactivity	Human, Mouse, Rat, Zebrafish
Validated Applications	WB, IP-Cell, IF-Tissue, IHC-P, FC
Molecular Weight	Predicted band size: 73 kDa
Positive Control	Jurkat cell lysate, HL-60 cell lysate, Hela cell lysate, MCF7 cell lysate, C2C12 cell lysate, L6 cell lysate, Mouse brain tissue lysate, Mouse heart tissue lysate, Rat brain tissue lysate, Rat heart tissue lysate, Zebrafish tissue lysate, HeLa, human kidney tissue, C2C12, human heart tissue, human liver tissue, mouse colon tissue, mouse skeletal muscle tissue, mouse testis tissue, mouse kidney tissue, rat kidney tissue, rat heart tissue, zebrafish tissue
Conjugation	unconjugated
Form	Liquid
Concentration	1μg/μl
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified

Data

Immunohistochemical staining of human kidney tissue using SDHA Rabbit Monoclonal Antibody (ARA900)

Immunohistochemical staining of human heart tissue using SDHA Rabbit Monoclonal Antibody (ARA900)

Immunohistochemical staining of human liver tissue using SDHA Rabbit Monoclonal Antibody (ARA900)

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Research Use Only

For Research Use Only. Not for use in diagnostic procedures.

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