p40 Rabbit Monoclonal Antibody(ARB829)

Datasheet

MSDS

Key features and details

Target: p40
Clone ID: ARB829
Source/Host: Rabbit
Reactivity: Human
Applications: IHC
Dilution: 1:100-1:200
Clonality: Monoclonal
Storage: at-20°C

Brand:

CAT.NO. : ARB6619

US$ Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

p40 antibody (antibody recognizing ΔNp63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential—a role that may be recapitulated in tumors derived from these cells.p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma.p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

Application

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

Application	Dilution Ratio
IHC	1:100 - 1:200

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Overview

Predicted Molecular Wt	66 kDa
Purity	ProA affinity purified IgG
Subcellular location	Nucleus
Swissprot ID	Q9H3D4-2
Immunogen	Synthetic peptide corresponding to p40 residues within aa1-100 of p40
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%
Recommended method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18° C-25° C) for 30 minutes.
Alternative Names	40 kDa Rab9 effector protein antibody, 8430412M01Rik antibody, 9530020d24rik antibody, AV073337 antibody, bA65N13.1 antibody, C87311 antibody, DKFZp686P1077 antibody, OTTHUMP00000022126 antibody, OTTMUSP00000012898 antibody, OTTMUSP00000012899 antibody, OTTMUSP00000041318 antibody, RAB9 effector p40 antibody, Rab9 effector protein with Kelch motifs antibody, RAB9p40 antibody, RABEK_HUMAN antibody, RABEPK antibody, RABEPK protein antibody, RGD1310612 antibody, RP11 65N13.1 antibody, RP23-446N16.2 antibody
Gene Symbol	TP63
Entrez Gene	8626

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Data

Immunohistochemical staining of human esophagus tissue sections was performed using p40 Rabbit Monoclonal Antibody (ARB829).

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Note

For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.

FAQs

Are the pathology antibodies provided by AREX raw antibodies or ready-to-use solutions?

AREX Biosciences specializes in supplying high-quality IHC pathology raw antibodies (Raw Antibodies). We do not manufacture ready-to-use working solutions or IVD diagnostic reagents. We mainly provide concentrated raw materials to pathology reagent manufacturers and diagnostic platform companies to support product development and OEM production.

What development scenarios are pathology raw antibodies mainly used for?

Our raw antibodies are primarily used for the research, performance optimization, validation, and commercial-scale production of pathology IHC detection reagents. They are also suitable for companion diagnostics (CDx) projects and antibody screening.

How can I evaluate whether a raw antibody is suitable for our staining platform?

It is recommended to focus on specificity, sensitivity, background control, and performance on your target automated platforms (such as Roche Ventana, Leica Bond, Agilent Dako, etc.). We can provide internal test data for reference, but we recommend partners perform actual validation on their own platforms.

Can you provide samples for platform validation?

Yes. We can provide validation samples depending on the specific product. Some products may be provided free of charge, while others may involve a small sample fee. Handling fee and shipping fee will be charged separately. Please contact us for detailed confirmation.

How should raw antibodies be paired with detection systems?

AREX raw antibodies can be used with various polymer detection systems and ancillary reagents. We recommend optimization in combination with the ARExVisual® system or your existing detection platform to achieve better signal intensity and background control.

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