ZAP-70 Mouse Monoclonal Antibody(ARM909)
Datasheet 
Key features and details
- Target:
- Clone ID:
- Source/Host:
- Reactivity:
- Applications:
- Dilution:
- Clonality:
- Storage:
-
Brand:
CAT.NO. : ARM6699
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Size:
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Product Details
Background
ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) is a protein coding gene located on human chromosome 2q11.2. ZAP70 is also known as SRK, STD, TZK, STCD, IMD48, ADMIO2 and ZAP-70. The human ZAP70 gene encodes a 69872 Da protein containing 619 amino acids. The ZAP70 protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are NF-KappaB Family Pathway and TCR Signaling (Qiagen). ZAP70 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. SYK is an important paralog of ZAP70 gene. ZAP70 is associated with some diseases, including Immunodeficiency 48 and Autoimmune Disease, Multisystem, Infantile-Onset, 2.
Application
To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.
*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.
Application | IHC |
Dilution Ratio | 1:50 - 1:200 |
Overview
Antibody Type | Primary antibodies |
Isotype | IgG2a |
Positive Control | Tonsil |
Localization | Cytoplasmic |
Form/Buffer | Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
Purification | Purified |
Conjugation | Unconjugated |
Alternative Names | Zeta-chain associated protein kinase 70kDa |
Gene Symbol | ZAP70 |
Entrez Gene | 7535 |
Uniprot | P43403 |
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.
Data
Immunohistochemistry analysis of Human Lymph Node sections labeling ZAP-70 with ZAP-70 Mouse Monoclonal Antibody(ARM909).
Research Use Only
For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
FAQs
Are the pathology antibodies provided by AREX raw antibodies or ready-to-use solutions?
AREX Biosciences specializes in supplying high-quality IHC pathology raw antibodies (Raw Antibodies). We do not manufacture ready-to-use working solutions or IVD diagnostic reagents. We mainly provide concentrated raw materials to pathology reagent manufacturers and diagnostic platform companies to support product development and OEM production.
What development scenarios are pathology raw antibodies mainly used for?
Our raw antibodies are primarily used for the research, performance optimization, validation, and commercial-scale production of pathology IHC detection reagents. They are also suitable for companion diagnostics (CDx) projects and antibody screening.
How can I evaluate whether a raw antibody is suitable for our staining platform?
It is recommended to focus on specificity, sensitivity, background control, and performance on your target automated platforms (such as Roche Ventana, Leica Bond, Agilent Dako, etc.). We can provide internal test data for reference, but we recommend partners perform actual validation on their own platforms.
Can you provide samples for platform validation?
Yes. We can provide validation samples depending on the specific product. Some products may be provided free of charge, while others may involve a small sample fee. Handling fee and shipping fee will be charged separately. Please contact us for detailed confirmation.
How should raw antibodies be paired with detection systems?
AREX raw antibodies can be used with various polymer detection systems and ancillary reagents. We recommend optimization in combination with the ARExVisual® system or your existing detection platform to achieve better signal intensity and background control.
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