Tyrosinase Rabbit Monoclonal Antibody(ARA914)
Key features and details
- Reactivity:
- Application:
- Host:
- Clonality:
- Target:
-
Brand:
CAT.NO. : ARA6749
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Size:
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Product Details
Background
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Defects in TYR are the cause of albinism oculocutaneous type 1B (OCA1B) [MIM:606952]; also known as albinism yellow mutant type. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:50-1:200 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Recombinant protein within Human Tyrosinase aa 1-340 / 529 |
|
Species Reactivity |
Human, Mouse |
|
Validated Applications |
WB, IF-Cell, IF-Tissue, IHC-P, IP, FC |
|
Molecular Weight |
Predicted band size: 60 kDa |
|
Positive Control |
SK-MEL-28 cell lysates, B16F1 cell lysates, SK-MEL-28, human liver tissue, human melanoma tissue |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human liver tissue using Tyrosinase Rabbit Monoclonal Antibody(ARA914)
Immunohistochemical staining of human melanoma tissue using Tyrosinase Rabbit Monoclonal Antibody(ARA914)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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