Recombinant Mouse VEGFR2 (C-Fc) Protein
Key features and details
- Product Description:
- Conjugate:
- Theoretical Molecular Weight:
- Apparent Molecular Weight:
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Brand:
CAT.NO. : AXP6640
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Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo.The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Overview
|
Product Description |
Recombinant Mouse Vascular Endothelial Growth Factor Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ala20-Glu762 is expressed with a human IgG1 Fc tag at the C-terminus. |
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Uniprot ID |
P35918 (Mouse) |
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Alternative Names |
Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1 |
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Conjugate |
Unconjugated |
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Theoretical Molecular Weight |
110 KDa |
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Apparent Molecular Weight |
140-170 KDa, reducing conditions |
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Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM NaH2PO4, 150mM NaCl, 0.1M Arg, 0.1M Glu, 0.01 %Tween20, pH7.4. |
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Endotoxin Level |
< 1 EU/µg as determined by LAL test. |
Data
Greater than 95% as determined by reducing SDS-PAGE.
Loaded Recombinant Mouse VEGFR2 (C-Fc) on Pro-A Biosensor, can bind Recombinant Mouse VEGF-D (C-6His) with an affinity constant of 1.61 nM as determined in BLI assay. (Regularly tested)
Storage
The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Upon receipt, store it immediately at the temperature listed below.
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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