pTau231 Mouse Monoclonal Antibody(ARA973)
Key features and details
- Reactivity:
- Application:
- Host:
- Clonality:
- Target:
-
Brand:
CAT.NO. : ARA6839
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Size:
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Product Details
Background
pTau231 is a phosphorylated form of tau protein that is a promising biomarker for early Alzheimer's disease (AD). It is an indicator of incipient amyloid-beta pathology and can be measured in blood plasma, making it useful for early detection, differentiating AD from other neurodegenerative disorders, and identifying people for clinical trials. Elevated levels correlate with cognitive and neuropathological severity, and it can detect AD changes years before clinical symptoms appear.
Application
|
Application |
Dilution Ratio |
|
ELISA |
1:250 - 1:500 |
Overview
|
Antibody Specificity |
Recognizing phosphorylated peptide (pT231) |
|
Species Reactivity |
Human |
|
Clonality |
Monoclonal |
|
Host / Isotype |
Mouse / IgM |
|
Immunogen |
Synthetic peptide within aa200-250 of Tau-F. The exact peptide sequence is proprietary information |
|
Cross Reactivity |
Not tested |
|
Recombinant |
Not recombinant |
|
Purification |
Protein A purification |
|
Form |
Liquid |
|
Conjugation |
Unconjugated |
Data
Sandwich ELISA analysis of pTau231 by ARA6839 & ARA6860.
Microtiter wells were coated with ARA6839 as the capture antibody. Synthetic peptides with different phosphorylation sites were used as the antigen. Peroxidase conjugated mouse anti-human Tau monoclonal antibody (ARA6860) was used as the detection antibody.
Result: ARA6839 and ARA6860 can be used as a matched antibody pair to detect and quantify the concentration of pTau231.
Cross reactivity of ARA6839 to other peptides and recombinant proteins by ELISA.
Microtiter wells were coated with various peptides and recombinant proteins.ARA6839 was used as the primary antibody and peroxidase conjugated goat anti-mouse IgM was used as the secondary antibody.
Result: ARA6839 does not cross-react with Tau peptide or recombinant proteins without any phosphorylation site.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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