Pax-5 Rabbit Monoclonal Antibody(ARA636)

Datasheet

MSDS

Pax-5 Rabbit Monoclonal Antibody(ARA636)

Key features and details

Target: PAX5
Clone ID: ARA636
Source/Host: Rabbit
Reactivity: Human
Clonality: Monoclonal
Application: IHC
Dilution: 1:500-1:1000
Storage: -20°C

Brand:

CAT.NO. : ARA6340

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Size:

1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

Paired box protein Pax-5 is a protein that in humans is encoded by the PAX5 gene. The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.

Application

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

Application	Dilution Ratio
IHC	1:500-1:1000

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Overview

Antibody Type	Primary antibodies
Isotype	IgG
Positive Control	Daudi cell lysate, Raji cell lysate, A20 cell lysate, Daudi, human appendix tissue, human B cell lymphoma tissue, human tonsil tissue, mouse spleen tissue, rat spleen tissue, A20.
Localization	Nucleus.
Form/Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Purification	Protein A affinity purified.
Alternative Names	B cell lineage specific activator antibody; B cell lineage specific activator protein antibody; B cell specific activator protein antibody; B cell specific transcription factor antibody; B-cell-specific transcription factor antibody; BSAP antibody; EBB-1 antibody; KLP antibody; Paired box 5 antibody; Paired box gene 5 (B cell lineage specific activator protein) antibody; Paired box gene 5 (B cell lineage specific activator) antibody; Paired box gene 5 antibody; Paired box homeotic gene 5 antibody; Paired box protein Pax 5 antibody; Paired box protein Pax-5 antibody; Paired domain gene 5 antibody; PAX 5 antibody; PAX5 antibody; PAX5_HUMAN antibody; Transcription factor PAX 5 antibody
Molecular Weight	Predicted band size: 42 kDa
Imnunogen	Recombinant protein within human PAX5 aa 101-391.
UniProt	Q02548(Human);Q02650(Mouse);

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Data

Immunohistochemical analysis of paraffin embedded human tonsil tissue using Pax-5 Rabbit Monoclonal Antibody(ARA636), ARExBx.

Immunohistochemical analysis of paraffin-embedded human appendix tissue with Pax-5 Rabbit Monoclonal Antibody(ARA636).

Storage

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Note

For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.

FAQs

Are the pathology antibodies provided by AREX raw antibodies or ready-to-use solutions?

AREX Biosciences specializes in supplying high-quality IHC pathology raw antibodies (Raw Antibodies). We do not manufacture ready-to-use working solutions or IVD diagnostic reagents. We mainly provide concentrated raw materials to pathology reagent manufacturers and diagnostic platform companies to support product development and OEM production.

What development scenarios are pathology raw antibodies mainly used for?

Our raw antibodies are primarily used for the research, performance optimization, validation, and commercial-scale production of pathology IHC detection reagents. They are also suitable for companion diagnostics (CDx) projects and antibody screening.

How can I evaluate whether a raw antibody is suitable for our staining platform?

It is recommended to focus on specificity, sensitivity, background control, and performance on your target automated platforms (such as Roche Ventana, Leica Bond, Agilent Dako, etc.). We can provide internal test data for reference, but we recommend partners perform actual validation on their own platforms.

Can you provide samples for platform validation?

Yes. We can provide validation samples depending on the specific product. Some products may be provided free of charge, while others may involve a small sample fee. Handling fee and shipping fee will be charged separately. Please contact us for detailed confirmation.

How should raw antibodies be paired with detection systems?

AREX raw antibodies can be used with various polymer detection systems and ancillary reagents. We recommend optimization in combination with the ARExVisual® system or your existing detection platform to achieve better signal intensity and background control.

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