NUS1 Rabbit Monoclonal Antibody(C2009)
Key features and details
- Target:
- Host:
- Reactivity:
- Clonality:
- Applications:
- Conjugation:
- Gene Symbol:
- Storage:
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Brand:
CAT.NO. : AMA01621
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Product Details
Background
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300).
Application
|
Application |
Dilution Ratio |
|
WB |
1:500 - 1:1000 |
Overview
|
Product Description |
Recombinant rabbit monoclonal antibody to NUS1 |
|
Immunogen |
Recombinant fusion protein of human NUS1. The exact sequence is proprietary. |
|
Purification Method |
The antibody was purified by immunogen affinity chromatography. |
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Clonality |
Monoclonal |
|
Form |
Liquid in PBS, pH 7.3, 50% glycerol, 0.05% BSA, and 0.05% Proclin300. |
|
Gene Symbol |
NUS1 |
|
Alternative Names |
C6orf68; NGBR; Nogo-B receptor; NgBR; Nuclear undecaprenyl pyrophosphate synthase 1 homolog |
|
Gene ID (Human) |
116150 |
|
Gene ID (Mouse) |
52014 |
|
Protein ID (Human) |
Q96E22 |
|
Protein ID (Mouse) |
Q99LJ8 |
Data
Western blot analysis of NUS1 expression in A549 (A) whole cell lysates. (Predicted band size: 33 kD; Observed band size: 32 kD)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Note
For Research Use Only. Not for use in diagnostic procedures.
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