LOM2 Rabbit Monoclonal Antibody(ARA640)

Datasheet

MSDS

Key features and details

Target: LOM2
Clone ID: ARA640
Source/Host: Rabbit
Reactivity: Human
Clonality: Monoclonal
Application: IHC
Dilution: 1:500-1:1000
Storage: -20°C

Brand:

CAT.NO. : ARA6344

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Size:

1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

The LIM-domain-only (LMO) family of proteins function as linkers in the co-regulation of nuclear transcription by mediating protein-protein interactions. The four members of the LMO family collectively have significant roles in cell fate determination, cell growth and differentiation, and organ development. LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms. LMO2 has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymphangiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma. The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin.

Application

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

Application	Dilution Ratio
IHC	1:500-1:1000

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Overview

Antibody Type	Primary antibodies
Isotype	IgG
Positive Control	K562 cell lysates, mouse brain tissue, human tonsil tissue, human lymph nodes tissue.
Localization	Nucleus.
Form/Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Purification	Protein A affinity purified.
Alternative Names	Cysteine rich protein TTG 2 antibody; Cysteine rich protein TTG2 antibody; Cysteine-rich protein TTG-2 antibody; LIM domain only 2 (rhombotin like 1) antibody; LIM domain only 2 antibody; LIM domain only protein 2 antibody; LMO 2 antibody; LMO-2 antibody; lmo2 antibody; RBTN 2 antibody; RBTN L1 antibody; RBTN2 antibody; RBTN2_HUMAN antibody; RBTNL 1 antibody; RBTNL1 antibody; RHOM 2 antibody; RHOM2 antibody; Rhombotin 2 antibody; Rhombotin like 1 antibody; Rhombotin-2 antibody; Rhombotin2 antibody; T cell translocation gene 2 antibody; T cell translocation protein 2 antibody; T-cell translocation protein 2 antibody; TTG 2 antibody; TTG2 antibody
Molecular Weight	Predicted band size: 18 kDa
Imnunogen	Recombinant protein full length human LMO2.
UniProt	P25791(Human);P25801(Mouse);

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Data

Immunohistochemical analysis of paraffin-embedded human tonsil tissue with LOM2 Rabbit Monoclonal Antibody(ARA640).

Immunohistochemical analysis of paraffin-embedded human lymph nodes tissue with LOM2 Rabbit Monoclonal Antibody(ARA640).

Storage

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Note

For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.

FAQs

Are the pathology antibodies provided by AREX raw antibodies or ready-to-use solutions?

AREX Biosciences specializes in supplying high-quality IHC pathology raw antibodies (Raw Antibodies). We do not manufacture ready-to-use working solutions or IVD diagnostic reagents. We mainly provide concentrated raw materials to pathology reagent manufacturers and diagnostic platform companies to support product development and OEM production.

What development scenarios are pathology raw antibodies mainly used for?

Our raw antibodies are primarily used for the research, performance optimization, validation, and commercial-scale production of pathology IHC detection reagents. They are also suitable for companion diagnostics (CDx) projects and antibody screening.

How can I evaluate whether a raw antibody is suitable for our staining platform?

It is recommended to focus on specificity, sensitivity, background control, and performance on your target automated platforms (such as Roche Ventana, Leica Bond, Agilent Dako, etc.). We can provide internal test data for reference, but we recommend partners perform actual validation on their own platforms.

Can you provide samples for platform validation?

Yes. We can provide validation samples depending on the specific product. Some products may be provided free of charge, while others may involve a small sample fee. Handling fee and shipping fee will be charged separately. Please contact us for detailed confirmation.

How should raw antibodies be paired with detection systems?

AREX raw antibodies can be used with various polymer detection systems and ancillary reagents. We recommend optimization in combination with the ARExVisual® system or your existing detection platform to achieve better signal intensity and background control.

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