Human Tau antibody pair (ARA6837/ARA958)
Datasheet 
Key features and details
- Target:
- Host:
- Reactivity:
- Clonality:
- Application:
- Storage:
-
Brand:
CAT.NO. : ARA6884
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Product Details
Background
Human Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. This internal skeleton has a tube-like shape through which molecules are transported across the cell. Tau stabilizes the microtubules that make up this skeleton to help them function best. Tau is found mostly in the messenger cells of our brains, called neurons, and is predominantly expressed in the neurons of the cerebral cortex where it has the highest abundance. In Alzheimer's disease, an abnormal form of tau accumulates and begins sticking together in thread-like structures called neurofibrillary tangles. These tangles are not effectively disposed of through the cell’s usual ways of removing “trash.” The build-up damages the disrupting how neurons function. Tau tangles start in the brainstem, which connects the brain to the spinal cord. Elevated tau levels are observed in the brain decades before the onset of Alzheimer’s disease symptoms like memory loss.
Application
The Tau Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.
Overview
Antibody Pair Specificity | Tau |
Species Reactivity | Human |
Protein Standard | Recombinant Human Tau Protein |
Target Antigen | Protein name: Microtubule-associated protein tau; Gene name: MAPT; Organism: Homo sapiens (Human) |
Cross Reactivity | Not Tested |
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.
Data
Microtiter wells were coated with ARA6837 at 2 µg/mL as the capture antibody. Recommbinant Tau protein (AXP6617) was used as the antigen. 100 ng/mL biotin conjugated Tau Antibody (ARA6807) was used as the detection antibody. Result: ARA6837 and ARA6807 can be used as a matched antibody pair to detect and quantify the concentration of Human Tau with high specificity.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| Tau Antibody (ARA6837) | ARA6837 | Mouse IgG2b | 100μg | Liquid |
| Tau Antibody (ARA6807) | ARA958 | Mouse IgG2a | 100μg | Liquid |
| Recombinant Human Tau Protein | AXP6617 | / | 20μg | Liquid |
Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Note
For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.
FAQs
What are the main types of research antibodies and how do they differ?
Research antibodies are mainly divided into monoclonal antibodies and polyclonal antibodies. Monoclonal antibodies typically offer higher specificity and better batch-to-batch consistency, while polyclonal antibodies often provide stronger affinity but may show more variation between batches. The choice depends on your specific experimental needs.
How can I tell if a research antibody is suitable for my experiment?
It is recommended to carefully review the product datasheet for validated applications, species reactivity, recommended dilutions, and published references. For new antibodies, performing a small-scale validation with positive control samples is usually helpful.
Can improper storage of research antibodies affect experimental results?
Yes. Antibodies are sensitive to temperature, repeated freeze-thaw cycles, and contamination. Improper storage may lead to reduced activity, increased background, or weaker signals. It is best to follow the storage instructions provided in the product datasheet.
Why doesn’t the recommended dilution in the datasheet work well in my experiment?
The recommended dilution is based on the supplier’s test conditions. Factors such as sample type, fixation method, and detection system in your lab can influence the optimal working concentration. Performing a dilution series optimization in your own system is often necessary.
What precautions should I take when using a newly purchased research antibody for the first time?
It is advisable to briefly centrifuge the antibody (especially concentrated or lyophilized ones), then perform a small-scale pilot experiment using the recommended conditions. Recording the batch number and usage date is also helpful for future tracking.
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