Human pTau181 Antibody Pair(ARA978/ARA971)
Key features and details
- Reactivity:
- Application:
- Host:
- Clonality:
- Target:
-
Brand:
CAT.NO. : ARA6852
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Size:
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Product Details
Background
Plasma phosphorylated tau 181 (p-tau181) has emerged as a promising biomarker for Alzheimer’s disease (AD) and related conditions. Studies show that elevated plasma p-tau181 levels are associated with increased amyloid-beta (Aβ) deposits across various brain regions in cognitively healthy adults. Furthermore, p-tau181 levels correlate with Aβ-positivity on positron emission tomography (PET), and they predict the conversion to dementia stage depending on tau-PET burden. However, p-tau181 does not appear to be directly linked to renal function. Additionally, plasma p-tau181 levels have been associated with cognitive decline in various populations, such as those with AD, mild cognitive impairment (MCI), and other neurodegenerative diseases. Moreover, p-tau181 levels have been identified as a noninvasive diagnostic and prognostic tool in clinical practice and trials.
Application
The pTau181 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| pTau181 Antibody | ARA6844 | Mouse IgG1 | 100μg | Liquid |
| Tau Antibody | ARA6837 | Mouse IgG2b | 100μg | Liquid |
| Recombinant Human p-Tau181 Protein | AXP6613 | / | 20μg | Liquid |
Overview
|
Antibody Pair Specificity |
pTau181 |
|
Species Reactivity |
Human |
|
Protein Standard |
Recombinant Human p-Tau181 Protein |
|
Target Antigen |
Protein name: Microtubule-associated protein tau; Gene name: MAPT ; Organism: Homo sapiens (Human) |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6844 at 0.5 µg/mL as the capture antibody. Recombinant pTau181 protein (Cat #: AXP6613) was used as the antigen. 200 ng/mL biotin conjugated Tau Antibody (ARA6837) was used as the detection antibody.
Result: ARA6844 and ARA6837 can be used as a matched antibody pair to detect and quantify the concentration of Human pTau181 with high specificity.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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