PD-1 Rabbit Monoclonal Antibody(ARB523)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6815
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Size:
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Product Details
Background
Programmed death 1 (PD-1)is a cell surface co-receptor in the CD28/CTLA-4 T-cellfamily and functions as a down regulator ofthe immune system through a dual mechanism of inhibition. PD-1 is expressed on activated T-cells, B-cells, and myeloid cells, and is a marker of angioimmunoblastic lymphoma andsuggests a unique cell of origin for this neoplasm. The presence of PD-1 positive tumor-infiltrating lymphocytes (TIL) has been associated with poor prognosis in human breastcancers and may be useful in antibody therapy targeting the PD-1/PD-L1 signaling pathway. Treatments targeting PD-1 and itsligand, PD-L1, have also shown encouraging results in non-small-cellung cancer, renal cell carcinoma and melanoma.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Product Description |
Rabbit monoclonal antibody to PD-1 |
|
Immunogen |
Recombinant full length protein corresponding to Human PD-1. The immunogen contains the specific extracellular domain of huPD1 (L25-Q167) |
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Purification Method |
ProA affinity purified |
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Molecular Weight |
Predicted band size: 32 kDa |
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Reactivity Species |
Human |
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Subcellular Location |
Membrane |
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Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. |
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Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
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SwissProt ID |
Q15116 |
Data
Storage
Store at -20°C. Stable for one year from the date of shipment
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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