Helicobactor pylori Rabbit Monoclonal Antibody(ARB587)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:Helicobactor pylori
-
Brand:
CAT.NO. : ARB6879
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Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
Helicobacter pylori is a spiral-shaped, microaerophilic, Gram-negative bacterium that colonizes the human gastric mucosa, utilizing polar flagella for motility and adhering to epithelial cells via adhesins (e.g., BabA, SabA). Its primary biological functions center on surviving the acidic gastric environment through urease activity, which hydrolyzes urea into ammonia and bicarbonate to neutralize stomach acid, establishing a niche for chronic persistence. The detection of Helicobacter pylori in clinical pathology specimens, primarily through histological examination of gastric biopsies (using stains such as Giemsa, Warthin-Starry or immunohistochemistry), provides critical diagnostic information. This is achieved by directly confirming active infection and visually correlating the bacteria's presence with the type and severity of associated mucosal damage, including chronic active gastritis, glandular atrophy, intestinal metaplasia and mucosal lymphoid follicles.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100-1:200 |
Overview
|
Species Cross-reactivity |
Helicobacter pylori |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Subcellular location |
Positive overall cytoplasm of Helicobacter pylori (gastric mucosal epithelium) |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes. |
|
Immunogen |
Tissue, cells or virus. |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human stomach tissue using Helicobactor pylori Rabbit Monoclonal Antibody(ARB587)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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