Cytokeratin 20 Rabbit Monoclonal Antibody(ARB938)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6730
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Size:
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Product Details
Background
Cytokeratin 20 is the simple-epithelial keratin with the most restricted expression pattern. For pair formation, its type II partner usually appears to be cytokeratin 8. The remarkable expression spectrum of cytokeratin 20 among normal tissues comprises gastric foveolar epithelium and small and large intestinal epithelium and, in addition, the urothelium and certain neuroendocrine cells, in particular Merkel cells of the skin. In tumor tissues, cytokeratin 20 is expressed in adenocarcinomas of the colon, stomach, pancreas, bile system and mucinous ovarian tumors, transitional cell carcinomas of the urinary tract, and Merkel cell carcinomas. Cytokeratin 20 is often used in conjunction with CK7 and other antibodies in distinguishing colon carcinomas (CK20+) from ovarian, pulmonary, and breast carcinomas.
Application
| Application | Dilution Ratio |
|---|---|
| IHC | 1:100-1:200 |
Overview
| Predicted Molecular Wt | 48kDa |
| Species Cross - reactivity | Human |
| Applications | IHC - P |
| Purity | ProA affinity purified IgG |
| Form | Liquid |
| Swissprot ID | P35900 |
| Subcellular location | Cytoplasm |
| Recommended method | Heat induced epitope retrieval with Tris - EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C - 25°C) for 30 minutes |
| Immunogen | Synthetic peptide corresponding to cytokeratin 20 residues within aa324 - 424 of cytokeratin 20 was used as an immunogen |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human colon adenocarcinoma tissue using Cytokeratin 20 Rabbit Monoclonal Antibody (ARB938).
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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