BCL-2 Rabbit Monoclonal Antibody(ARA941)
Key features and details
- Reactivity:
- Application:
- Host:
- Clonality:
- Target:
-
Brand:
CAT.NO. : ARA6782
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Size:
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Product Details
Background
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architectur. Isoforms that lack the repressor domain are more active than isoform 1. Expressed in brain and skeletal muscle. Expression is highest during the early stages of postnatal development, at later stages levels greatly decrease.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:1,000-1:5,000 |
Overview
|
Antibody Type |
Recombinant Rabbit Monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human Bcl2 alpha aa 50 - 150 (N terminal). |
|
Species Reactivity |
Human |
|
Validated Applications |
WB, IHC - P, IF - Cell, FC |
|
Molecular Weight |
Predicted band size: 26 kDa |
|
Positive Control |
MCF7 cell lysate, Jurkat cell lysate, HL - 60 cell lysate, THP - 1 cell lysate, human B - cell lymphoma tissue, human tonsil tissue, human lymph nodes tissue, HeLa, THP - 1 |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human B-cell lymphoma tissue using BCL-2 Rabbit Monoclonal Antibody(ARA941)
Immunohistochemical staining of human tonsil tissue using BCL-2 Rabbit Monoclonal Antibody(ARA941)
Immunohistochemical staining of human lymph nodes tissue using BCL-2 Rabbit Monoclonal Antibody(ARA941)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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