Thrombomodulin Rabbit Monoclonal Antibody(ARA646)

MSDS

Thrombomodulin Rabbit Monoclonal Antibody(ARA646)

Key features and details

Target: Thrombomodulin
Host: Rabbit
Reactivity: Human
Clonality: Monoclonal
Applications: IHC
Conjugation: Unconjugated
Storage: -20°C

Brand:

CAT.NO. : ARA6352

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Size:

1mL

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Product Details

Background

Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI, aka carboxypeptidase B2) into its active form. Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome (aHUS).

Application

Application	Dilution Ratio
IHC	1:200 - 1:1000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Recombinant protein within human Thrombomodulin aa 201-515.
Species Reactivity	Human
Applications	IHC
Predicted Molecular Weight	60 kDa
Conjugate	Unconjugated
Form	Liquid
Storage Buffer	1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype	IgG
Purification Method	Protein A affinity purified.
Uniprot ID	P07204 (Human)
Alternative Names	AHUS 6, AHUS6, BDCA 3, BDCA3, CD 141, CD141, CD141 antigen, Fetomodulin, Thbd, THPH12, THRM, Thrombomodulin, TM, TRBM_HUMAN