SNF5 Rabbit Monoclonal Antibody(ARB548)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6840
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Size:
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Product Details
Background
SNF5, one of the core subunits of the SWI/SNF complex, is necessary for efficient nucleosome remodeling by BRG1 in vitro. SMARCB1/BAF47 is an essential part of the esBAF (mouse embryonic stem cell specific SWI/SNF complex) and is necessary for early embryogenesis and hepatocyte differentiation. In addition, SNF5 is considered to be a tumor suppressor protein; inactivating mutations have been indentified in a large number of malignant rhabdoid tumors.
SNF5 is widely expressed in normal tissues and tumor tissues, but is often absent in malignant rhabdomyosarcoma and epithelioid sarcoma.
SNF5 antibodies have been used to distinguish between atypical teratoid/rhabdomyosid tumors (SNF5 deletion) and choroid plexus carcinoma (SNF5 positive), and between epithelioid sarcoma (SNF5 deletion) and epithelioid hemangioendothelioma (SNF5 positive).
SNF5 is widely expressed in normal tissues and tumor tissues, but is often absent in malignant rhabdomyosarcoma and epithelioid sarcoma.
SNF5 antibodies have been used to distinguish between atypical teratoid/rhabdomyosid tumors (SNF5 deletion) and choroid plexus carcinoma (SNF5 positive), and between epithelioid sarcoma (SNF5 deletion) and epithelioid hemangioendothelioma (SNF5 positive).
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
44kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
Q12824 |
|
Subcellular location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Recombinant protein fragment of SNF5 was used as an immunogen. |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human colon disease tissue using SNF5 Rabbit Monoclonal Antibody(ARB548)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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