SDHB Rabbit Monoclonal Antibody(ARA641)

Datasheet

MSDS

Key features and details

Target: SDHB
Clone ID: ARA641
Source/Host: Rabbit
Reactivity: Human
Clonality: Monoclonal
Application: IHC
Dilution: 1:500-1:1000
Storage: -20°C

Brand:

CAT.NO. : ARA6345

US＄ Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity).

Application

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

Application	Dilution Ratio
IHC	1:500-1:1000

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Overview

Antibody Type	Primary antibodies
Isotype	IgG
Positive Control	K-562 cell lysate, HEK-293 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, Mouse liver tissue lysate, Rat liver tissue lysate, K-562, NIH/3T3, human liver cancer tissue, human kidney tissue, rat kidney tissue, mouse kidney tissue, PC-12.
Localization	Mitochondrion inner membrane.
Form/Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Purification	Protein A affinity purified.
Alternative Names	CWS2 antibody; DHSB_HUMAN antibody; FLJ92337 antibody; Ip antibody; Iron sulfur subunit antibody; Iron sulfur subunit of complex II antibody; Iron-sulfur subunit of complex II antibody; mitochondrial antibody; PGL 4 antibody; PGL4 antibody; SDH 1 antibody; SDH antibody; SDH1 antibody; SDH2 antibody; SDH2, homolog of antibody; SdhB antibody; SDHIP antibody; Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial antibody; Succinate dehydrogenase [ubiquinone] iron sulfur subunit antibody; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit antibody; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial antibody; Succinate Dehydrogenase 1 Iron Sulfur Subunit antibody; Succinate Dehydrogenase 2, S. cerevisiae, homolog of antibody; Succinate dehydrogenase complex iron sulfur subunit B antibody; Succinate dehydrogenase complex subunit B iron sulfur antibody; Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein antibody; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) antibody; Succinate dehydrogenase iron sulfur protein antibody
Molecular Weight	Predicted band size: 32 kDa
Imnunogen	Synthetic peptide within human SDHB aa 1-280 / 280.
UniProt	P21912(Human);Q9CQA3(Mouse);P21913(Rat);

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Data

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue with SDHB Rabbit Monoclonal Antibody(ARA641).

Immunohistochemical analysis of paraffin-embedded human kidney tissue with SDHB Rabbit Monoclonal Antibody(ARA641).

Storage

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Note

For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.

FAQs

Are the pathology antibodies provided by AREX raw antibodies or ready-to-use solutions?

AREX Biosciences specializes in supplying high-quality IHC pathology raw antibodies (Raw Antibodies). We do not manufacture ready-to-use working solutions or IVD diagnostic reagents. We mainly provide concentrated raw materials to pathology reagent manufacturers and diagnostic platform companies to support product development and OEM production.

What development scenarios are pathology raw antibodies mainly used for?

Our raw antibodies are primarily used for the research, performance optimization, validation, and commercial-scale production of pathology IHC detection reagents. They are also suitable for companion diagnostics (CDx) projects and antibody screening.

How can I evaluate whether a raw antibody is suitable for our staining platform?

It is recommended to focus on specificity, sensitivity, background control, and performance on your target automated platforms (such as Roche Ventana, Leica Bond, Agilent Dako, etc.). We can provide internal test data for reference, but we recommend partners perform actual validation on their own platforms.

Can you provide samples for platform validation?

Yes. We can provide validation samples depending on the specific product. Some products may be provided free of charge, while others may involve a small sample fee. Handling fee and shipping fee will be charged separately. Please contact us for detailed confirmation.

How should raw antibodies be paired with detection systems?

AREX raw antibodies can be used with various polymer detection systems and ancillary reagents. We recommend optimization in combination with the ARExVisual® system or your existing detection platform to achieve better signal intensity and background control.

New Products

CD74 Mouse Monoclonal Antibody(ARA635)

Human CD74 Mouse Monoclonal Antibody Pair(ARA634/ARA635)

CRBN Rabbit Monoclonal Antibody(ARA644)

HEK293 HCP ELISA Kit

E.coli HCP ELISA Kit