RUNX2 Rabbit Monoclonal Antibody(ARA674)

Key features and details

Reactivity: Human
Application: IHC, IF, WB, FC, IP
Host: Rabbit
Clonality: Monoclonal
Target: RUNX2

Brand:

CAT.NO. : ARA6392

US$ Please choose

Size:

100μL 1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.

Application

Application	Dilution Ratio
IHC	1:200 - 1:1000

Overview

Product Description	Recombinant Rabbit monoclonal Antibody
Immunogen	Recombinant protein within human 300-450.
Purification Method	Protein A affinity purified.
Clonality	Monoclonal
Form	Liquid
Storage Buffer	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype	IgG
Validated Applications	IHC, IF, WB, FC, IP
Reactivity Species	Human
Molecular Weight	Predicted band size: 57 kDa
Positive Control	MDA-MB-231 cell lysate, Saos-2 cell lysate, NIH/3T3 cell lysate, Saos-2, SW480, human tonsil tissue, human colon tissue, human spleen tissue, mouse bone tissue, rat maxilla tissue, C2C12.
Conjugation	unconjugated