PAX-5(BSAP) Mouse Monoclonal Antibody(ARM901)

Datasheet

MSDS

PAX-5(BSAP) Mouse Monoclonal Antibody(ARM901)

Key features and details

Target: PAX-5(BSAP)
Clone ID: ARM901
Source/Host: Mouse
Reactivity: Human
Applications: IHC
Dilution: 1:100-1:200
Clonality: Monoclonal
Storage: -20°C

Brand:

CAT.NO. : ARM6691

US$ Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

PAX-5 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. The PAX-5 gene encodes the B-cell lineage specific activator protein (BSAP), whose expression is limited to early stages of B-cell differentiation. Anti-PAX-5 is useful in differentiating between classic Hodgkin's lymphoma versus multiple myeloma and solitary plasmacytoma, as the protein is expressed in mature and precursor B-cell non-Hodgkin's lymphomas/leukemias while being absent from the other two conditions. Diffuse large B-cell lymphomas are positive for PAX-5, with the exception of those with terminal B-cell differentiation, and T-cell neoplasms do not stain with Anti-PAX-5.

Application

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

Application	IHC
Dilution Ratio	1:100- 1:200

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Overview

Antibody Type	Primary antibodies
Form/Buffer	Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Purification	Purified
Conjugation	Unconjugated
Alternative Names	B cell lineage specific activator antibody, B cell lineage specific activator protein antibody, B cell specific activator protein antibody, B cell specific transcription factor antibody, B-cell-specific transcription factor antibody, BSAP antibody, EBB-1 antibody, KLP antibody, Paired box 5 antibody, Paired box gene 5 (B cell lineage specific activator protein) antibody, Paired box gene 5 (B cell lineage specific activator) antibody, Paired box gene 5 antibody, Paired box homeotic gene 5 antibody, Paired box protein Pax 5 antibody, Paired box protein Pax-5 antibody, Paired domain gene 5 antibody, PAX 5 antibody, PAX5 antibody, PAX5_HUMAN antibody, Transcription factor PAX 5 antibody
Gene Symbol	PAX5
Entrez Gene	5079
Uniprot	Q02548

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Data

Immunohistochemical staining of human tonsil tissue using PAX-5 (BSAP) Mouse Monoclonal Antibody (ARM901).

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Research Use Only

For Research Use Only. Not for diagnostic, therapeutics, prophylactic or in vivo use.

FAQs

Are the pathology antibodies provided by AREX raw antibodies or ready-to-use solutions?

AREX Biosciences specializes in supplying high-quality IHC pathology raw antibodies (Raw Antibodies). We do not manufacture ready-to-use working solutions or IVD diagnostic reagents. We mainly provide concentrated raw materials to pathology reagent manufacturers and diagnostic platform companies to support product development and OEM production.

What development scenarios are pathology raw antibodies mainly used for?

Our raw antibodies are primarily used for the research, performance optimization, validation, and commercial-scale production of pathology IHC detection reagents. They are also suitable for companion diagnostics (CDx) projects and antibody screening.

How can I evaluate whether a raw antibody is suitable for our staining platform?

It is recommended to focus on specificity, sensitivity, background control, and performance on your target automated platforms (such as Roche Ventana, Leica Bond, Agilent Dako, etc.). We can provide internal test data for reference, but we recommend partners perform actual validation on their own platforms.

Can you provide samples for platform validation?

Yes. We can provide validation samples depending on the specific product. Some products may be provided free of charge, while others may involve a small sample fee. Handling fee and shipping fee will be charged separately. Please contact us for detailed confirmation.

How should raw antibodies be paired with detection systems?

AREX raw antibodies can be used with various polymer detection systems and ancillary reagents. We recommend optimization in combination with the ARExVisual® system or your existing detection platform to achieve better signal intensity and background control.

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