FGFR3 Rabbit Monoclonal Antibody(ARA915)
Key features and details
- Reactivity:
- Application:
- Host:
- Clonality:
- Target:
-
Brand:
CAT.NO. : ARA6750
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Size:
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Product Details
Background
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-3 maps to chromosome 4p16 and is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR-3 are associated with several diseases, including Crouzon syndrome, achondroplasia, thanatophoric dysplasia, craniosynostosis adelaide type and hypochondroplasia. Mutations in FGFR-3 are also a cause of some bladder and cervical cancers.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:500-1:2000 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human FGFR3 aa 30-63 / 806 |
|
Species Reactivity |
Human, Mouse (Predicted: Rat) |
|
Validated Applications |
WB, IF-Cell, IF-Tissue, IHC-P |
|
Molecular Weight |
Predicted band size: 88 kDa |
|
Positive Control |
Hela cell lysate, 293 cell lysate, MCF-7 cell lysate, HepG2 cell lysate, Rat skin tissue lysates, Mouse hippocampus lysates, MCF-7, HepG2, SH-SY5Y, human kidney tissue, mouse testis tissue, mouse kidney tissue, mouse brain tissue |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/μl |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical staining of human bladder cancer tissue using FGFR3 Rabbit Monoclonal Antibody(ARA915)
Immunohistochemical staining of human kidney tissue using FGFR3 Rabbit Monoclonal Antibody(ARA915)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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