Antibodi Poliklonal Kelinci NMDAR2B

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Fitur dan detail utama

Antibodi poliklonal kelinci terhadap NMDAR2B

Sasaran: NMDAR2B
Sumber/Pembawa Acara: Kelinci
Reaktivitas: Manusia, Tikus, Tikus
Klonalitas: Poliklonal
Aplikasi: WB
Konjugasi: Tidak terkonjugasi
Penyimpanan: pada-20°C

Merek:

KUCING.TIDAK. : APA11447

US$ Silakan pilih

Ukuran:

50μL 100μL

Trail, Bulk size or Custom requests Please contact us

Detail Produk

Latar Belakang

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) . Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents . Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) .

Aplikasi

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

WB	1:500 - 1:1000

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Ikhtisar

Deskripsi	Antibodi poliklonal kelinci terhadap NMDAR2B
Kekhususan	Recognizes endogenous levels of NMDAR2B protein.
Tipe Antibodi	Antibodi primer
Imunogen	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NMDAR2B. The exact sequence is proprietary.
Pemurnian	The antibody was purified by immunogen affinity chromatography.
Berat Molekul	Prediksi: 166 kD; Teramati : 190 kD
Formulir/Penyangga	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Nama Alternatif	NMDAR2B; Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-Methyl-D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3
Simbol Gen	GRIN2B
Entrez Gene	2904 (Manusia); 14812(Tikus); 24410(Tikus)
SwissProt	Q13224(Human); Q01097(Mouse); Q00960(Rat)

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Data

Western blot analysis of NMDAR2B expression in rat brain (A), mouse brain (B), U87MG (C) whole cell lysates. (Predicted band size: 166 kD; Observed band size: 190 kD)

Penyimpanan

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Catatan

For Research Use Only. Not for use in diagnostic procedures.

FAQ

What are the main types of research antibodies and how do they differ?

Research antibodies are mainly divided into monoclonal antibodies and polyclonal antibodies. Monoclonal antibodies typically offer higher specificity and better batch-to-batch consistency, while polyclonal antibodies often provide stronger affinity but may show more variation between batches. The choice depends on your specific experimental needs.

How can I tell if a research antibody is suitable for my experiment?

It is recommended to carefully review the product datasheet for validated applications, species reactivity, recommended dilutions, and published references. For new antibodies, performing a small-scale validation with positive control samples is usually helpful.

Can improper storage of research antibodies affect experimental results?

Yes. Antibodies are sensitive to temperature, repeated freeze-thaw cycles, and contamination. Improper storage may lead to reduced activity, increased background, or weaker signals. It is best to follow the storage instructions provided in the product datasheet.

Why doesn’t the recommended dilution in the datasheet work well in my experiment?

The recommended dilution is based on the supplier’s test conditions. Factors such as sample type, fixation method, and detection system in your lab can influence the optimal working concentration. Performing a dilution series optimization in your own system is often necessary.

What precautions should I take when using a newly purchased research antibody for the first time?

It is advisable to briefly centrifuge the antibody (especially concentrated or lyophilized ones), then perform a small-scale pilot experiment using the recommended conditions. Recording the batch number and usage date is also helpful for future tracking.

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