PDE1C Rabbit Polyclonal Antibody

Sicherheitsdatenblatt

Key features and details

Rabbit polyclonal antibody to PDE1C

Ziel: PDE1C
Quelle/Host: Kaninchen
Reaktivität: Mensch, Maus, Ratte
Klonalität: Polyklonal
Anwendungen: WB
Konjugation: Unkonjugiert
Lagerung: bei -20°C

Marke:

KAT.-NR. : APA16443

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Größe:

50μL 100 μL

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Produktdetails

Hintergrund

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has a high affinity for both cAMP and cGMP . Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

Bewerbung

To ensure optimal assay performance, AREX recommends conducting reagent titration tailored to each testing system for optimal detection results.

WB	1:500 - 1:2000

*Results are sample-specific. Please refer to your local assay conditions and test parameters for reference.

Übersicht

Beschreibung	Rabbit polyclonal antibody to PDE1C
Spezifität	Recognizes endogenous levels of PDE1C protein
Antikörpertyp	Primärer Antikörper
Immunogen	Recombinant fusion protein of human PDE1C. The exact sequence is proprietary.
Reinigung	The antibody was purified by immunogen affinity chromatography.
Molekulargewicht	Predicted: 72; Observed: 81 kD
Form/Puffer	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Alternative Namen	Calcium/calmodulin-dependent 3' 5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; hCam-3
Gensymbol	PDE1C
Entrez Gene	5137(Human); 18575(Mouse); 81742(Rat)
SwissProt	Q14123(Human); Q64338(Mouse); Q63421(Rat)

*AREX continuously optimizes our products. Webpage content may not reflect the latest updates. For inquiries, please contact info@arexbio.com or your local distributor.
*Clone Number, Reactivity, Source/Host and Clonality can be found in the product name and Key Features section above.

Daten

Western blot analysis of PDE1C expression in HepG2 (A), mouse testis (B), rat heart (C), rat brain (D) whole cell lysates. (Predicted band size: 72; 80; 86 kD; Observed band size: 81 kD)

Lagerung

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Hinweis

For Research Use Only. Not for use in diagnostic procedures.

FAQs

What are the main types of research antibodies and how do they differ?

Research antibodies are mainly divided into monoclonal antibodies and polyclonal antibodies. Monoclonal antibodies typically offer higher specificity and better batch-to-batch consistency, while polyclonal antibodies often provide stronger affinity but may show more variation between batches. The choice depends on your specific experimental needs.

How can I tell if a research antibody is suitable for my experiment?

It is recommended to carefully review the product datasheet for validated applications, species reactivity, recommended dilutions, and published references. For new antibodies, performing a small-scale validation with positive control samples is usually helpful.

Can improper storage of research antibodies affect experimental results?

Yes. Antibodies are sensitive to temperature, repeated freeze-thaw cycles, and contamination. Improper storage may lead to reduced activity, increased background, or weaker signals. It is best to follow the storage instructions provided in the product datasheet.

Why doesn’t the recommended dilution in the datasheet work well in my experiment?

The recommended dilution is based on the supplier’s test conditions. Factors such as sample type, fixation method, and detection system in your lab can influence the optimal working concentration. Performing a dilution series optimization in your own system is often necessary.

What precautions should I take when using a newly purchased research antibody for the first time?

It is advisable to briefly centrifuge the antibody (especially concentrated or lyophilized ones), then perform a small-scale pilot experiment using the recommended conditions. Recording the batch number and usage date is also helpful for future tracking.

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